“Cochrane Schizophrenia Group’s register (May 2007) and MEDLINE (September 2007) were conducted for randomized, blinded studies comparing two or more of nine second-generation antipsychotics in the treatment of schizophrenia. 78 study Meta 13.5k patients combined result Tx Positive/Negative/Subscales/Dropout:
1.💊Olanzapine💊 proved superior to aripiprazole, quetiapine, risperidone, and ziprasidone.
2. 💊Risperidone💊 was more efficacious than quetiapine and ziprasidone.
3. 💊Clozapine💊 proved superior to zotepine and, in doses >400 mg/day, to risperidone. These differences were due to improvement in positive symptoms rather than negative symptoms. The results were rather robust with regard to the effects of industry sponsorship, study quality, dosages, and trial duration.” (AmJPsychi 2009)
All data were extracted by at least three reviewers independently. The primary outcome measure was change in total score on the Positive and Negative Syndrome Scale; secondary outcome measures were positive and negative symptom subscores and rate of dropout due to inefficacy. The results were combined in a meta-analysis. Various sensitivity analyses and metaregressions were used to examine bias.
2.1 Inject & Forget Neurolept Anti Psychotics:
2.2 Head To Head Neurolept Anti Psychotics
There were no significant differences between amisulpride and olanzapine (N=701), risperidone (N=291), and ziprasidone (N=122).
Aripiprazole was less efficacious than olanzapine in two studies sponsored by aripiprazole’s manufacturer (N=794, weighted mean difference=5.0, p=0.002). Two further studies found no significant difference compared with risperidone (N=372).
Clozapine was not significantly different from olanzapine (N=619), quetiapine (N=232), risperidone (N=466), and ziprasidone (N=146). Clozapine was significantly more efficacious than zotepine (N=59, weighted mean difference=–6.0, p=0.002). The comparison with risperidone was significantly heterogeneous due to one study sponsored by clozapine’s manufacturer (17) ; excluding the study did not change the overall results.
Olanzapine was significantly more efficacious than aripiprazole (N=794, weighted mean difference=–5.0, p=0.002), quetiapine (N=1,449, weighted mean difference=–3.7, p<0.001), risperidone (N=2,404, weighted mean difference=–1.9, p=0.006), and ziprasidone (N=1,291, weighted mean difference=–8.3, p<0.001). No significant difference between olanzapine and amisulpride (N=701) or clozapine (N=619) emerged.
Quetiapine was significantly less efficacious than olanzapine (N=1,449, weighted mean difference=3.7, p<0.001) and risperidone (N=1,953, weighted mean difference=3.2, p=0.003). There was no significant difference compared with clozapine (N=232) and ziprasidone (N=710).
Risperidone was significantly more efficacious than quetiapine (N=1,953, weighted mean difference=–3.2, p=0.003) and ziprasidone (N=1,016, weighted mean difference=–4.6, p=0.002). It was less efficacious than olanzapine (N=2,404, weighted mean difference=1.9, p=0.006). No difference compared with amisulpride (N=291), aripiprazole (N=372), clozapine (N=466), and sertindole (N=493) emerged.
There was no significant difference between sertindole and risperidone in two studies sponsored by sertindole’s manufacturer, one in treatment-resistant patients, which found results with risperidone to be 7 points better, the other without this criterion finding sertindole 3.5 points better (N=493), leading to significant heterogeneity.
Ziprasidone was less efficacious than olanzapine (N=1,291, weighted mean difference=8.3, p<0.001) and risperidone (N=1,016, weighted mean difference=4.6, p=0.002). No significant differences compared with amisulpride (N=122), clozapine (N=146), and quetiapine (N=710) were found.
Zotepine was less efficacious than clozapine (N=59, weighted mean difference=6.0, p=0.002).
Dosing reference to 10mg oral Dz.
Opioid *(See Ed Nb II)
Tramadol is a non poppy derived semi synthetic opioid-esk mu primary ag (tad more complex than that). (ANZCA a2018).
Concerns Regarding Malpractice Runs Into The Billions (Pharma Settlements)
Forensic Psychiatrist Dr Yolande Lucire, PhD MD: Moral Panic, Drug Reactions & Prescribing Behaviors (Au)
Ethics & Abuse In Human Pharmacological Research (U of Tulsa College of Law)
Joanna Moncrieff: The Chemical Cure Myth – Politics of Psychiatric Drug Treatment
Dr David Healy: The Pharmaceutical Python (Yale Psychiatry)
Ivan Oransky, MD: Fraud & Retractions In Medical Science – (NYU)
Prof of Medicine & Statistics Ioannidis: Medical Research Is Broken (Stanford)
Neuropsychopharmacology Prof David Nutt – The Inconvenient Truth About Drugs – (Imperial College London)
Diagnostic and Therapeutic Controversies – All Faculty (EmergencyMed)
UNM Psychiatry GR: Succeeding With Psychotic Illness Mark Vonnegut, M.D.
Diagnostic & Medical/Research Error List.
*Ed Nb I
[If Your Pain Is Being Under Managed, Because Your Physician Is Treating You Like A “Drug Seeker” Since The “Opioid Crisis” – Especially In A Single Night Emergency – You May Want To Consider A Law Suit Against The Company+Clinic+Clinician(s): And I Would Never Say That Lightly. But Only Legal Action Early Can Keep This In Check.
95% Of All Patients Were Not “Drug Seekers”, With Doctors Doing Nothing About It Because They Had To Wait To Be Told. We Should Not Be Practicing Medicine, Based On Discrimination And Guesses, At Which 5% *May* Get High – As If True Drug Seekers Won’t Always Find A Way Anyway. The New Guidelines Hurt Only The People They Are Not Targeted At. And Generate Underground Markets That Did Not Previously Exist. Medicine Is Not Policing.
If You Have Launched Any Legal Action, Please Contact The Author With Your Story, Or For Further Information On Class Actions As They Develop. FEB2018].